Checkpoints: Chromosome pairing takes an unexpected twist

被引：10

作者：

Meier, B

Ahmed, S

机构：

[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 21期

关键词：

D O I：

10.1016/S0960-9822(01)00518-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When meiotic cells complete S phase, homologous chromosomes pair, synapse and undergo recombination. A checkpoint protein is somehow required for meiotic chromosome pairing in C. elegans, thus providing a direct link between S phase and the rest of the meiotic program.

引用

收藏

页码：R865 / R868

页数：4

相关论文

共 29 条

[1] MRT-2 checkpoint protein is required for germline immortality and telomere replication in C-elegans [J].

Ahmed, S ;

Hodgkin, J .

NATURE, 2000, 403 (6766) :159-164

[2] Meiotic recombination in C-elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis [J].

Dernburg, AF ;

McDonald, K ;

Moulder, G ;

Barstead, R ;

Dresser, M ;

Villeneuve, AM .

CELL, 1998, 94 (03) :387-398

[3] A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins [J].

Edwards, RJ ;

Bentley, NJ ;

Carr, AM .

NATURE CELL BIOLOGY, 1999, 1 (07) :393-398

[4] Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1 [J].

Emili, A ;

Schieltz, DW ;

Yates, JR ;

Hartwell, LH .

MOLECULAR CELL, 2001, 7 (01) :13-20

[5] Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes [J].

Flaggs, G ;

Plug, AW ;

Dunks, KM ;

Mundt, KE ;

Ford, JC ;

Quiggle, MRE ;

Taylor, EM ;

Westphal, CH ;

Ashley, T ;

Hoekstra, MF ;

Carr, AM .

CURRENT BIOLOGY, 1997, 7 (12) :977-986

[6] Functional genomic analysis of C-elegans chromosome I by systematic RNA interference [J].

Fraser, AG ;

Kamath, RS ;

Zipperlen, P ;

Martinez-Campos, M ;

Sohrmann, M ;

Ahringer, J .

NATURE, 2000, 408 (6810) :325-330

[7] Human and mouse homologs of Schizosaccharomyces pombe rad1+ and Saccharomyces cerevisiae RAD17:: linkage to checkpoint control and mammalian meiosis [J].

Freire, R ;

Murguía, JR ;

Tarsounas, M ;

Lowndes, NF ;

Moens, PB ;

Jackson, SP .

GENES & DEVELOPMENT, 1998, 12 (16) :2560-2573

[8] A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans [J].

Gartner, A ;

Milstein, S ;

Ahmed, S ;

Hodgkin, J ;

Hengartner, MO .

MOLECULAR CELL, 2000, 5 (03) :435-443

[9]

Grushcow JM, 1999, GENETICS, V153, P607

[10]

HAWLEY RS, 1993, TRENDS GENET, V9, P310