Fluorous synthesis of allylic fluorides: C-F bond formation as the detagging process

被引：19

作者：

Boldon, Sophie ^{[1
]}

Moore, Jane E. ^{[2
]}

Gouverneur, Veronique ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[2] AstraZeneca UK, Macclesfield SK10 4TG, Cheshire, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 31期

关键词：

D O I：

10.1039/b804484h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel fluorous tagging-detagging strategy has been developed featuring a fluorination as the detagging process; fluorous allylsilanes were prepared by cross-metathesis and subsequently subjected to electrophilic fluorodesilylation; Selectfluor was used as the detagging reagent; the resulting allylic fluorides were successfully purified by fluorous solid phase extraction.

引用

收藏

页码：3622 / 3624

页数：3

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