Recent advances in the development of GTR/GBR membranes for periodontal regeneration-A materials perspective

被引:685
作者
Bottino, Marco C. [1 ]
Thomas, Vinoy [2 ]
Schmidt, Gudrun [3 ]
Vohra, Yogesh K. [2 ]
Chu, Tien-Min Gabriel [1 ]
Kowolik, Michael J. [4 ,5 ]
Janowski, Gregg M. [6 ]
机构
[1] Indiana Univ Sch Dent, Dept Restorat Dent, Div Dent Biomat, Indianapolis, IN 46202 USA
[2] Univ Alabama Birmingham, CNMB, Birmingham, AL 35294 USA
[3] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA
[4] Indiana Univ Sch Dent, Dept Periodont, Indianapolis, IN 46202 USA
[5] Indiana Univ Sch Dent, Allied Dent Programs, Indianapolis, IN 46202 USA
[6] Univ Alabama Birmingham, Dept Mat Sci & Engn, Birmingham, AL 35294 USA
关键词
Periodontitis; Periodontal regeneration; Scaffolds; Electrospinning; Hydrogels; Hydroxyapatite; Drug delivery; Membranes; Guided tissue regeneration; GUIDED BONE REGENERATION; TISSUE ENGINEERING APPLICATIONS; DERMAL MATRIX GRAFT; HYDROXYAPATITE/COLLAGEN/PLGA COMPOSITE MEMBRANE; NANOFIBROUS NANOCOMPOSITE SCAFFOLDS; COLLAGEN BARRIER MEMBRANES; BETA-TRICALCIUM PHOSPHATE; CROSS-LINKING AGENT; MECHANICAL-PROPERTIES; GINGIVAL RECESSION;
D O I
10.1016/j.dental.2012.04.022
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional membranes possess many structural, mechanical, and bio-functional limitations and the "ideal" membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). Objective. This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR membranes as well as the recent advances on the processing and characterization of GTR/GBR membranes from a materials perspective. Significance. Studies of spatially designed and functionally graded membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering. (C) 2012 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:703 / 721
页数:19
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