Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

被引：267

作者：

Kverka, M. ^{[2
]}

Zakostelska, Z. ^{[2
]}

Klimesova, K. ^{[2
]}

Sokol, D. ^{[2
]}

Hudcovic, T. ^{[4
]}

Hrncir, T. ^{[4
]}

Rossmann, P. ^{[2
]}

Mrazek, J. ^{[3
]}

Kopecny, J. ^{[3
]}

Verdu, E. F. ^{[1
]}

Tlaskalova-Hogenova, H. ^{[2
]}

机构：

[1] McMaster Univ, FFDHRI, Hamilton, ON L8N 3Z5, Canada

[2] Acad Sci Czech Republ, Inst Microbiol, Prague, Czech Republic

[3] Acad Sci Czech Republ, Inst Anim Physiol & Genet, Prague, Czech Republic

[4] Novy Hradek, Prague, Czech Republic

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2011年 / 163卷 / 02期

关键词：

animal models; cytokines/interleukins; DSS colitis; inflammatory bowel disease; microbiota; INFLAMMATORY-BOWEL-DISEASE; SULFATE-INDUCED COLITIS; TUMOR-NECROSIS-FACTOR; CROHNS-DISEASE; INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; DEXTRAN SULFATE; MAINTAINING REMISSION; IMMUNODEFICIENT MICE; INTERFERON-GAMMA;

D O I：

10.1111/j.1365-2249.2010.04286.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology. The anti-colitic effect of oral mPd was not observed in severe combined immunodeficient mice and probably involved induction of specific antibody responses and stabilization of the intestinal microbiota. Our results suggest that specific bacterial components derived from the commensal bacterium, P. distasonis, may be useful in the development of new therapeutic strategies for chronic inflammatory disorders such as inflammatory bowel disease.

引用

页码：250 / 259

页数：10

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