Modulation of calcium and potassium currents by lamotrigine

被引：49

作者：

Grunze, H

von Wegerer, J

Greene, RW

Walden, J

机构：

[1] Univ Munich, Psychiat Klin, D-80336 Munich, Germany

[2] Univ Freiburg, Klin Psychiat & Psychosomat, Freiburg, Germany

[3] Harvard Univ, Sch Med, Brockton, MA 02401 USA

[4] Harvard Univ, Vet Affairs Med Ctr, Brockton, MA 02401 USA

来源：

NEUROPSYCHOBIOLOGY | 1998年 / 38卷 / 03期

关键词：

lamotrigine; calcium; potassium; carbamazepine; valproate; verapamil; epilepsy; bipolar disorder;

D O I：

10.1159/000026528

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CAI and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage-gated - calcium currents and the transient potassium outward current ID. These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating: underlying cellular disturbances in bipolar disorder.

引用

页码：131 / 138

页数：8

共 38 条

[1] A potassium channel mutation in neonatal human epilepsy
Biervert, C
Schroeder, BC
Kubisch, C
Berkovic, SF
Propping, P
Jentsch, TJ
Steinlein, OK
[J]. SCIENCE, 1998, 279 (5349) : 403 - 406
[2] BINGMANN D, 1989, EXP BRAIN RES, V74, P239
[3] WHOLE CELL RECORDING FROM NEURONS IN SLICES OF REPTILIAN AND MAMMALIAN CEREBRAL-CORTEX
BLANTON, MG
LOTURCO, JJ
KRIEGSTEIN, AR
[J]. JOURNAL OF NEUROSCIENCE METHODS, 1989, 30 (03) : 203 - 210
[4] OPEN TRIAL OF A CALCIUM-ANTAGONIST, NIMODIPINE, IN ACUTE MANIA
BRUNET, G
CERLICH, B
ROBERT, P
DUMAS, S
SOUETRE, E
DARCOURT, G
[J]. CLINICAL NEUROPHARMACOLOGY, 1990, 13 (03) : 224 - 228
[5] Calabrese JR, 1996, AM J PSYCHIAT, V153, P1236
[6] Dubovsky SL, 1997, J CLIN PSYCHIAT, V58, P224
[7] CALCIUM-ANTAGONISTS IN MANIC-DEPRESSIVE ILLNESS
DUBOVSKY, SL
[J]. NEUROPSYCHOBIOLOGY, 1993, 27 (03) : 184 - 192
[8] ZINC MODULATES A-TYPE POTASSIUM CURRENTS AND NEURONAL EXCITABILITY IN SNAIL NEURONS
ERDELYI, L
[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY, 1994, 14 (06) : 689 - 700
[9] Grunze H, 1997, MAGNESIUM RES, V10, P119
[10] GRUNZE H, 1997, J BIOPOLAR DISORDER, V1, P2

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