Reconstitution of CD4+ T lymphocytes in HIV-infected individuals following antiretroviral therapy

被引：98

作者：

Carcelain, G ^{[1
]}

Debré, P ^{[1
]}

Autran, B ^{[1
]}

机构：

[1] Hop La Pitie Salpetriere, Lab Immunol Cellulaire & Tissulaire, INSERM, U543, F-75013 Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00245-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune reconstitution during antiretroviral therapy has recently been shown to depend upon multiple factors at work in T cell homeostasis, amongst which the reduction of thymus dysfunction and of immune hyperactivation are instrumental. The optimism that has been raised by the restoration of hosts' defenses against opportunistic pathogens is, however, balanced by the poor immunity restored against HIV; thus, innovative immune interventions are required.

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页码：483 / 488

页数：6

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