Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood?

被引：24

作者：

Dunkel, IJ ^{[1
]}

OMalley, B ^{[1
]}

Finlay, JL ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT RADIOL,NEW YORK,NY 10021

来源：

PEDIATRIC NEUROSURGERY | 1996年 / 24卷 / 05期

关键词：

brain stem tumor; chemotherapy; stem cell rescue; autologous;

D O I：

10.1159/000121049

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diffuse pontine tumors are highly lethal and conventional therapy with irradiation provides long-term survival to a very small proportion of the patients. We have reported promising results using high-dose chemotherapy with autologous stem cell rescue in patients with recurrent high-grade astrocytomas in other anatomic locations, but our results and those of others have been very discouraging in children with brain stem tumors. Alternative strategies need to be developed for this highly lethal disease.

引用

页码：263 / 266

页数：4

共 14 条

[1] DUNKEL I, 1994, PEDIATR NEUROSURG, V21, P219
[2] Dunkel I. J., 1994, Bone Marrow Transplantation, V14, pS64
[3] HIGH-DOSE MULTIAGENT CHEMOTHERAPY FOLLOWED BY BONE-MARROW RESCUE FOR MALIGNANT ASTROCYTOMAS OF CHILDHOOD AND ADOLESCENCE
FINLAY, JL
AUGUST, C
PACKER, R
ZIMMERMAN, R
SUTTON, L
FREID, A
RORKE, L
BAYEVER, E
KAMANI, N
KRAMER, E
COHEN, B
STURGILL, B
NACHMAN, J
STRANDJORD, S
TURSKI, P
FRIERDICH, S
STEEVES, R
JAVID, M
[J]. JOURNAL OF NEURO-ONCOLOGY, 1990, 9 (03) : 239 - 248
[4] RANDOMIZED PHASE-III TRIAL IN CHILDHOOD HIGH-GRADE ASTROCYTOMA COMPARING VINCRISTINE, LOMUSTINE, AND PREDNISONE WITH THE 8-DRUGS-IN-1-DAY REGIMEN
FINLAY, JL
BOYETT, JM
YATES, AJ
WISOFF, JH
MILSTEIN, JM
GEYER, JR
BERTOLONE, SJ
MCGUIRE, P
CHERLOW, JM
TEFFT, M
TURSKI, PA
WARA, WM
EDWARDS, M
SUTTON, LN
BERGER, MS
EPSTEIN, F
AYERS, G
ALLEN, JC
PACKER, RJ
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (01) : 112 - 123
[5] FINAL RESULTS OF A STUDY OF ESCALATING DOSES OF HYPERFRACTIONATED RADIOTHERAPY IN BRAIN-STEM TUMORS IN CHILDREN - A PEDIATRIC-ONCOLOGY-GROUP STUDY
FREEMAN, CR
KRISCHER, JP
SANFORD, RA
COHEN, ME
BURGER, PC
DELCARPIO, R
HALPERIN, EC
MUNOZ, L
FRIEDMAN, HS
KUN, LE
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 27 (02): : 197 - 206
[6] HEIDEMAN RL, 1989, CANCER RES, V49, P736
[7] KALIFA C, 1992, BONE MARROW TRANSPL, V9, P227
[8] HIGH-DOSE CHEMOTHERAPY WITH MARROW REINFUSION AND HYPERFRACTIONATED IRRADIATION FOR CHILDREN WITH HIGH-RISK BRAIN-TUMORS
KEDAR, A
MARIA, BL
GRAHAMPOLE, J
RINGDAHL, DM
QUISLING, RG
MICKLE, JP
MENDENHALL, NP
MARCUS, RB
GROSS, S
[J]. MEDICAL AND PEDIATRIC ONCOLOGY, 1994, 23 (05): : 428 - 436
[9] KRETSCHMAR CS, 1993, CANCER-AM CANCER SOC, V72, P1404, DOI 10.1002/1097-0142(19930815)72:4<1404::AID-CNCR2820720441>3.0.CO
[10] 2-G

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