Matrix Metalloproteinase-9 in an Exploratory Trial of Intravenous Minocycline for Acute Ischemic Stroke

被引：123

作者：

Switzer, Jeffrey A. ^{[1
,2
,3
]}

Hess, David C. ^{[2
,3
]}

Ergul, Adviye ^{[2
,3
]}

Waller, Jennifer L. ^{[2
,3
]}

Machado, Livia S. ^{[6
]}

Portik-Dobos, Vera ^{[2
,3
]}

Pettigrew, L. Creed ^{[4
]}

Clark, Wayne M. ^{[5
]}

Fagan, Susan C. ^{[6
]}

机构：

[1] Georgia Hlth Sci Univ, Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

[2] Georgia Hlth Sci Univ, Dept Physiol, Augusta, GA 30912 USA

[3] Georgia Hlth Sci Univ, Dept Biostat, Augusta, GA 30912 USA

[4] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA

[5] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[6] Univ Georgia, Coll Pharm, Athens, GA 30602 USA

来源：

STROKE | 2011年 / 42卷 / 09期

基金：

美国国家卫生研究院;

关键词：

acute stroke; inflammation; neuroprotection; MATRIX-METALLOPROTEINASE EXPRESSION; THROMBOLYSIS;

D O I：

10.1161/STROKEAHA.111.618215

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Plasma matrix metalloproteinase-9 levels predict posttissue plasminogen activator (tPA) hemorrhage. Methods-The authors investigated the effect of minocycline on plasma matrix metalloproteinase-9 in acute ischemic stroke in the Minocycline to Improve Neurological Outcome in Stroke (MINOS) trial and a comparison group. Results-Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P = 0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P < 0.0001; non-tPA, P = 0.0019). Conclusions-Lower plasma matrix metalloproteinase-9 was seen among tPA-treated subjects in the MINOS trial. Combining minocycline with tPA may prevent the adverse consequences of thrombolytic therapy through suppression of matrix metalloproteinase-9 activity. (Stroke. 2011;42:2633-2635.)

引用

页码：2633 / 2635

页数：3

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