The design and evaluation of heparin-binding foldamers

被引：67

作者：

Choi, S

Clements, DJ

Pophristic, V

Ivanov, I

Vemparala, S

Bennett, JS

Klein, ML

Winkler, JD

DeGrado, WE ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[3] Univ Sci Philadelphia, Dept Chem & Biochem, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Med, Div Hematol & Oncol, Philadelphia, PA 19104 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 41期

关键词：

antithrombin; heparin; inhibitors; oligomers; protein interactions;

D O I：

10.1002/anie.200501279

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Controlling blood loss: The synthesis of a series of arylamide oligomers 1, which interact with heparin is described. The heparin-small molecule interaction inhibits the heparin's ability to activate antithrombin. These arylamide oligomers are the first example of low-molecular-weight antagonists that inhibit the anticoagulant function of heparin. (Chemical Equation Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6685 / 6689

页数：5

共 33 条

[1] Electrostatics of nanosystems: Application to microtubules and the ribosome [J].