Computer-aided tissue engineering: application to biomimetic modelling and design of tissue scaffolds

被引:150
作者
Sun, W [1 ]
Starly, B [1 ]
Darling, A [1 ]
Gomez, C [1 ]
机构
[1] Drexel Univ, Coll Engn, Dept Mech Engn & Mech, Lab Comp Aided Tissue Engn, Philadelphia, PA 19104 USA
关键词
bone scaffold; computer-aided design (CAD); computer-aided tissue engineering (CATE); tissue engineering; tissue scaffold design;
D O I
10.1042/BA20030109
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Computer-aided tissue engineering (CATE) enables many novel approaches in modelling, design and fabrication of complex tissue substitutes with enhanced functionality and improved cell-matrix interactions. Central to CATE is its bio-tissue informatics model that represents tissue biological, biomechanical and biochemical information that serves as a central repository to interface design, simulation and tissue fabrication. The present paper discusses the application of a CATE approach to the biomimetic design of bone tissue scaffold. A general CATE-based process for biomimetic modelling, anatomic reconstruction, computer-assisted-design of tissue scaffold, quantitative-computed-tomography characterization, finite element analysis and freeform extruding deposition for fabrication of scaffold is presented.
引用
收藏
页码:49 / 58
页数:10
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