Computer-aided tissue engineering: application to biomimetic modelling and design of tissue scaffolds

被引：150

作者：

Sun, W ^{[1
]}

Starly, B ^{[1
]}

Darling, A ^{[1
]}

Gomez, C ^{[1
]}

机构：

[1] Drexel Univ, Coll Engn, Dept Mech Engn & Mech, Lab Comp Aided Tissue Engn, Philadelphia, PA 19104 USA

来源：

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY | 2004年 / 39卷

关键词：

bone scaffold; computer-aided design (CAD); computer-aided tissue engineering (CATE); tissue engineering; tissue scaffold design;

D O I：

10.1042/BA20030109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Computer-aided tissue engineering (CATE) enables many novel approaches in modelling, design and fabrication of complex tissue substitutes with enhanced functionality and improved cell-matrix interactions. Central to CATE is its bio-tissue informatics model that represents tissue biological, biomechanical and biochemical information that serves as a central repository to interface design, simulation and tissue fabrication. The present paper discusses the application of a CATE approach to the biomimetic design of bone tissue scaffold. A general CATE-based process for biomimetic modelling, anatomic reconstruction, computer-assisted-design of tissue scaffold, quantitative-computed-tomography characterization, finite element analysis and freeform extruding deposition for fabrication of scaffold is presented.

引用

页码：49 / 58

页数：10

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