Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats

被引：66

作者：

Chen, Li-Min ^{[1
,2
]}

Zhou, Xiao-Mian ^{[2
]}

Cao, Ying-Lin ^{[2
]}

Hu, Wen-Xiang ^{[1
]}

机构：

[1] Capital Normal Univ, Inst Phys Organ & Med Chem, Beijing 100037, Peoples R China

[2] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 05期

关键词：

ginsenoside Re; cerebral ischemia; reperfusion injury; H+-ATPase; mitochondrial swelling;

D O I：

10.1080/10286020801892292

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the present study, we have investigated the neuroprotective potential of ginsenoside Re (Re) in the middle cerebral artery occlusion model in Sprague-Dawley rats. Adult male Sprague-Dawley rats were treated with Re (5, 10 or 20mgkg-1, P.O. for 7 days, once a day) prior to occlusion. There was a significant increase in the neurological symptoms in ischemic animals as compared with the sham group animals. These effects were attenuated by 10 and 20 mg kg(-1) Re, P.O. There was a significant increase in the level of malondialdehyde (MDA) in ischemic animals indicating oxidative stress. An elevated level of MDA in ischemic animals was reduced by 10 and 20 mg kg(-1) Re, P.O., respectively. It was observed that Re significantly decreased mitochondrial swelling, thereby preventing the reduction of H+-ATPase activity. This study demonstrates the neuroprotective potential of Re in cerebral ischemia-reperfusion injury in rats.

引用

页码：439 / 445

页数：7

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