Carbon nanohorns as anticancer drug carriers

被引：345

作者：

Ajima, Kumiko ^{[1
]}

Yudasaka, Masako ^{[1
]}

Murakami, Tatsuya ^{[2
]}

Maigne, Alan ^{[1
,3
]}

Shiba, Kiyotaka ^{[4
]}

Ijima, Sumio ^{[1
,5
]}

机构：

[1] NEC Corp Ltd, JST SORST, Tsukuba, Ibaraki 3058501, Japan

[2] Japanese Fdn Canc Res, Inst Canc, JST SORST, Dept Prot Engn, Tokyo 1708455, Japan

[3] CNRS, Phys Solides Lab, UMR 8502, F-91405 Orsay, France

[4] Japanese Fdn Canc Res, Inst Canc, Dept Prot Engn, Tokyo 1708455, Japan

[5] Meijo Univ, Tenpaku Ku, Nagoya, Aichi 4688502, Japan

来源：

MOLECULAR PHARMACEUTICS | 2005年 / 2卷 / 06期

关键词：

carbon nanotube; carbon nanohorn; anticancer drug; drug carrier; cisplatin;

D O I：

10.1021/mp0500566

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The released cisplatin was effective in terminating the growth of human lung-cancer cells, while the SWNHs themselves had no such effect. Cisplatin-incorporated oxidized SWNHs are thus a potential drug delivery system.

引用

页码：475 / 480

页数：6

共 31 条

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