Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action

被引：90

作者：

Pohlmann, J

Lampe, T

Shimada, M

Nell, PG

Pernerstorfer, J

Svenstrup, N

Brunner, NA

Schiffer, G

Freiberg, C ^{[1
]}

机构：

[1] Bayer AG, Dept Antiinfect Res, D-42096 Wuppertal, Germany

[2] Bayer AG, Dept Med Chem, D-42096 Wuppertal, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 04期

关键词：

pyrrolidine diones; moiramide B; andrimid; acetyl-CoA carboxylase; antibiotic;

D O I：

10.1016/j.bmcl.2004.12.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure activity relationship (SAR) studies revealed a high degree of variability for the fatty acid side chain, allowing optimization of physicochemical parameters, and a restricted SAR for the pyrrolidinedione group, indicating major relevance of this subunit for efficient target binding. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1189 / 1192

页数：4

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