First-trimester screening: An overview

被引：7

作者：

Eiben, B ^{[1
]}

Glaubitz, R ^{[1
]}

机构：

[1] Inst Clin Genet Nordrheim, D-46047 Oberhausen, Germany

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2005年 / 53卷 / 03期

关键词：

first-trimester screening; free beta-hCG; PAPP-A; nasal bone; trisomy; 21; chromosomal aberrations; sonography; NT; heart defects; maternal age;

D O I：

10.1369/jhc.4B6420.2005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An improvement in prenatal screening for chromosomal defects has been achieved by combining sonography and biochemical markers. Analyzing markers taken from maternal blood such as pregnancy-associated plasma protein A and free beta-human chorionic gonadotropin in combination with the ultrasound marker nuchal translucency provides detection rates of 90% for the most important chromosomal anomalies. In addition, nuchal translucency is a marker for severe heart defects. This report discusses the potential of new markers such as the nasal bone.

引用

页码：281 / 283

页数：3

共 17 条

[1]

[Anonymous], 11 14 WEEK SCAN DIAG

[2] Absence of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an observational study [J].