Control of cleavage cycles in Drosophila embryos by fruhstart

被引：50

作者：

Grosshans, J

Müller, HAJ

Wieschaus, E

机构：

[1] Univ Heidelberg, ZMBH, D-69120 Heidelberg, Germany

[2] Princeton Univ, Dept Mol Biol, Howard Hughes Med Inst, Princeton, NJ 08540 USA

[3] Univ Dusseldorf, Inst Genet, D-40225 Dusseldorf, Germany

来源：

DEVELOPMENTAL CELL | 2003年 / 5卷 / 02期

关键词：

D O I：

10.1016/S1534-5807(03)00208-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Early metazoan development consists of cleavage stages characterized by rapid cell cycles that successively divide the fertilized egg. The cell cycle oscillator pauses when the ratio of DNA and cytoplasm (N/C) reaches a threshold characteristic for the species. This pause requires maternal factors as well as zygotic expression of as yet unknown genes. Here we isolate the zygotic gene fruhstart of Drosophila and show that it is involved in pausing the cleavage cell cycle. frs is expressed immediately after the last cleavage division. It plays a role in generating a uniform pause and it can inhibit cleavage divisions when precociously expressed. Furthermore, the expression of frs is delayed in haploid embryos and requires activity of the maternal checkpoint gene grapes. We propose that zygotic frs expression is involved in linking the N/C and the pause of cleavage

引用

页码：285 / 294

页数：10

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