A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

被引：290

作者：

Kochi, Y

Yamada, R ^{[1
]}

Suzuki, A

Harley, JB

Shirasawa, S

Sawada, T

Bae, SC

Tokuhiro, S

Chang, XT

Sekine, A

Takahashi, A

Tsunoda, T

Ohnishi, Y

Kaufman, KM

Kang, CSP

Kang, CW

Otsubo, S

Yumura, W

Mimori, A

Koike, T

Nakamura, Y

Sasazuki, T

Yamamoto, K

机构：

[1] RIKEN, SNP Res Ctr, Lab Rheumat Dis, Yokohama, Kanagawa 2300045, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo 1130033, Japan

[3] Univ Oklahoma, Oklahoma City, OK 73104 USA

[4] US Dept Vet Affairs, Oklahoma City, OK 73104 USA

[5] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA

[6] Int Med Ctr Japan, Tokyo 1628655, Japan

[7] Hanyang Univ, Hosp Rheumat Dis, Div Rheumatol, Dept Internal Med, Seoul 133792, South Korea

[8] RIKEN, SNP Res Ctr, Lab SNP Anal, Yokohama, Kanagawa 2300045, Japan

[9] RIKEN, SNP Res Ctr, Lab Genotyping, Yokohama, Kanagawa 2300045, Japan

[10] RIKEN, SNP Res Ctr, Lab Med Informat, Yokohama, Kanagawa 2300045, Japan

[11] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[12] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan

[13] Tokyo Womens Med Univ, Kidney Ctr, Dept Med, Tokyo 1628666, Japan

[14] Hokkaido Univ, Sch Med, Dept Med 2, Sapporo, Hokkaido 0608638, Japan

[15] RIKEN, SNP Res Ctr, Res Grp Personalized Med, Yokohama, Kanagawa 2300045, Japan

来源：

NATURE GENETICS | 2005年 / 37卷 / 05期

关键词：

D O I：

10.1038/ng1540

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis ( odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappa B and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.

引用

页码：478 / 485

页数：8

共 53 条

[1] An anti-rheumatic agent T-614 inhibits NF-κB activation in LPS- and TNF-α-stimulated THP-1 cells without interfering with 1κBα degradation [J].