Menorrhagia and bleeding disorders

被引:44
作者
El-Hemaidi, Ihab
Gharaibeh, Amer
Shehata, Hassan
机构
[1] Epsom Univ Hosp NHS Trust, Carshalton SM5 1AA, Surrey, England
[2] Queen Elizabeth Hosp, Dept Haematol, London, England
[3] St George Hosp, Sch Med, London, England
[4] St Heier Univ Hosp NHS Trust, Carshalton SM5 1AA, Surrey, England
关键词
menorrhagia; platelet function disorders; von Willebrand's; disease;
D O I
10.1097/GCO.0b013e3282f1ddbe
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
Purpose of review Menorrhagia affects 30% of women in reproductive age. Once referred to a gynaecologist, possible c bleeding disorders are not routinely investigated and the risk of surgical intervention is high. This may lead to an increase in surgical complications and a negative health and psychological impact on women as well as an unnecessary financial burden on the health service. Recent findings Although the estimated community prevalence of bleeding disorders is 2%, these disorders are consistently reported to affect 10-20% of women with objectively documented menorrhagia and to be even higher in adolescents. Recently, underlying bleeding disorders, particularly von Willebrand's disease and platelet function disorders, have been found to be prevalent in women with menorrhagia' This article critically appraises the current literature in this field. Summary In the UK, 20% of all women, and 30% in the USA, have a hysterectomy before the age of 60; menorrhagia is the main presenting problem in at least 50-70%. In approximately 50% of cases, no organic pathology is determined, and dysfunctional uterine bleeding is diagnosed. Diagnosis and management of bleeding disorders may possibly reduce the need for surgical intervention, leading to a positive impact on women and the health service.
引用
收藏
页码:513 / 520
页数:8
相关论文
共 84 条
[1]
ADCOCK DM, 2002, COAGULATION HDB
[2]
Agarwal M B, 1992, Indian Pediatr, V29, P837
[3]
Identification of a novel mutation in a non-Jewish factor XI deficient kindred [J].
Alhaq, A ;
Mitchell, M ;
Sethi, M ;
Rahman, S ;
Flynn, G ;
Boulton, P ;
Caeno, G ;
Smith, M ;
Savidge, G .
BRITISH JOURNAL OF HAEMATOLOGY, 1999, 104 (01) :44-49
[4]
Factor V deficiency and menstruation: A gynecologic challenge [J].
Bennett, K ;
Daley, ML ;
Pike, C .
OBSTETRICS AND GYNECOLOGY, 1997, 89 (05) :839-840
[5]
AN ACQUIRED BERNARD-SOULIER-LIKE PLATELET DEFECT ASSOCIATED WITH JUVENILE MYELODYSPLASTIC SYNDROME [J].
BERNDT, MC ;
KABRAL, A ;
GRIMSLEY, P ;
WATSON, N ;
ROBERTSON, TI ;
BRADSTOCK, KF .
BRITISH JOURNAL OF HAEMATOLOGY, 1988, 68 (01) :97-101
[6]
The rare coagulation disorders - review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation [J].
Bolton-Maggs, PHB ;
Perry, DJ ;
Chalmers, EA ;
Parapia, LA ;
Wilde, JT ;
Williams, MD ;
Collins, PW ;
Kitchen, S ;
Dolan, G ;
Mumford, AD .
HAEMOPHILIA, 2004, 10 (05) :593-628
[7]
BORELDERLON A, 1999, THROMB HAEMOST S, V341, P1079
[8]
BURGESS C, 2001, HAEMOPHILIA, pB247
[9]
INDICATIONS FOR AND OUTCOME OF TOTAL ABDOMINAL HYSTERECTOMY FOR BENIGN DISEASE - A PROSPECTIVE COHORT STUDY [J].
CLARKE, A ;
BLACK, N ;
ROWE, P ;
MOTT, S ;
HOWLE, K .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1995, 102 (08) :611-620
[10]
CLETON FJ, 1980, THROMB DIATH HAEMO, V17, P268