A General and Selective Iron-Catalyzed Aminocarbonylation of Alkynes: Synthesis of Acryl- and Cinnamides

被引：102

作者：

Driller, Katrin Marie ^{[1
]}

Prateeptongkum, Saisuree ^{[1
]}

Jackstell, Ralf ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 02期

关键词：

acrylamides; carbonylation; cinnamides; homogeneous catalysis; iron; CROSS-COUPLING REACTIONS; P-ARYLTHIO CINNAMIDES; EFFICIENT SYNTHESIS; ALPHA; BETA-UNSATURATED AMIDES; CARBONYL-COMPLEXES; (E)-ALPHA; TRANSFER HYDROGENATION; ALLYLIC SUBSTITUTION; CYCLOBUTENEDIONES; METAL;

D O I：

10.1002/anie.201005823

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Entering the iron age: The first general method for iron-catalyzed monocarbonylation of alkynes has been developed. A range of structurally diverse cinnamides and acrylamides have been obtained smoothly starting from commercially available amines and alkynes in the presence of [Fe 3(CO)12] and ligand L (see scheme). The method is highly chemo- and regioselective and requires no expensive catalyst. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：537 / 541

页数：5

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