Gene arrangement of the killer cell inhibitory receptor family on human chromosome 19q13.4 detected by fiber FISH

被引：26

作者：

Suto, Y

Ishikawa, Y

Kasahara, M

Kasai, F

Yabe, T

Akaza, T

Juji, T

机构：

[1] Japanese Red Cross Cent Blood Ctr, Dept Res, Shibuya Ku, Tokyo 150, Japan

[2] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Tokyo, Japan

[3] Grad Univ Adv Studies, Dept Biosyst Sci, Hayama 2400193, Japan

[4] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, Tokyo 113, Japan

来源：

IMMUNOGENETICS | 1998年 / 48卷 / 04期

关键词：

natural killer cell; killer cell inhibitory receptor; immunoglobulin superfamily; human chromosome 19; fiber-FISH;

D O I：

10.1007/s002510050427

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human chromosome 19q13.4 has recently been revealed to be a remarkable region harboring multiple receptor genes of the immunoglobulin (Ig) superfamily differentially expressed on hematopoietic cell lineages. Over the past few years, more than 50 cDNAs have been cloned for the natural killer cell inhibitory receptor (KIR) gene family, which possess two or three Ig-like domains in the extracellular region. In this study, using two genomic DNA probes containing intron sequences of genes corresponding to the two- and three-domain types, we applied two-color-fluorescence in situ hybridization on stretched DNA fiber preparations (fiber-FISH). As a result, 11 positions homologous to KIR genes were found as a cluster within a range of approximately 120 kilobases on a chromatin fiber from human chromosome 19.

引用

页码：235 / 241

页数：7

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