A Versatile Sugar Transferase Makes the Cut

被引：5

作者：

Hanover, John A. ^{[1
]}

机构：

[1] NIDDK, Cellular & Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2011年 / 144卷 / 03期

关键词：

CELL-PROLIFERATION; HCF-1;

D O I：

10.1016/j.cell.2011.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.

引用

页码：321 / 323

页数：4

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