Lysis of photosensitized erythrocytes in an alternating magnetic field

被引：5

作者：

Babincová, M

Leszczynska, D

Sourivong, P

Babinec, P

机构：

[1] Comenius Univ, MFF UK, Dept Biophys & Chem Phys, Bratislava 84215, Slovakia

[2] FSU, FAMU, Coll Engn, Dept Civil Engn, Tallahassee, FL 32310 USA

[3] Univ N Dakota, Dept Phys, Grand Forks, ND 58202 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2001年 / 225卷 / 1-2期

关键词：

hematoporphyrin; AC magnetic field; singlet oxygen; erythrocyte; cancer treatment; photodynamic therapy; radical formation; cell lysis; light exposure;

D O I：

10.1016/S0304-8853(00)01257-9

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Exposure of human erythrocytes photosensitized with hematoporphyrin dihydrochloride to a magnetic field (180 kHz, 4.6 kA/m) resulted in time- and hematoporphyrin-concentration-dependent lysis. The singlet oxygen scavenger histidine inhibited lysis, indicating the direct involvement of radicals in erythrocyte lysis. Exposure not only to light but also to an AC magnetic field may thus enhance the efficiency of photodynamic tumor therapy. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：194 / 196

页数：3

共 15 条

[1]

Babincová M, 1999, Z NATURFORSCH C, V54, P993

[2] ALTERATIONS IN ERYTHROCYTE BAND-3 ORGANIZATION INDUCED BY THE PHOTOSENSITIZER, HEMATOPORPHYRIN DERIVATIVE [J].