Antioxidant and prooxidant activities of elderberry (Sambucus nigra) extract in low-density lipoprotein oxidation

被引:79
作者
Abuja, PM
Murkovic, M
Pfannhauser, W
机构
[1] Graz Univ, SFB Biomembrane Res Ctr, Inst Biochem, A-8010 Graz, Austria
[2] Graz Univ Technol, Inst Biochem & Food Chem, A-8010 Graz, Austria
关键词
antioxidants; anthocyanins; lipid peroxidation; low-density lipoprotein; Sambucus nigra;
D O I
10.1021/jf980296g
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Spray-dried elderberry juice, containing high amounts of anthocyanin glucosides, was investigated for its antioxidant and prooxidant potentials and mechanisms. A strong, concentration-dependent prolongation of the lag phase of copper-induced oxidation of human low-density lipoprotein (LDL) was found, but the maximum oxidation rate was unchanged. Peroxyl-radical-driven LDL oxidation showed both prolongation of lag time and reduction of maximum oxidation rate. In the case of copper-mediated oxidation, the anthocyanins were able to reduce alpha-tocopheroxyl radical to alpha-tocopherol. Clear prooxidant activity in copper-mediated oxidation was observed, depending on the time of addition of extract: whenever the extract was present from the beginning or added within the first 10 min; the antioxidant effect prevailed. Addition at later times led to a considerable reduction of lag phase and increase of maximum oxidation rate. No such effect was found in peroxyl-radical-mediated LDL oxidation; on the contrary, the extract was even able to-reduce the propagation rate considerably.
引用
收藏
页码:4091 / 4096
页数:6
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