European randomized study of prostate cancer screening:: first-year results of the Finnish trial

被引:58
作者
Määttänen, L
Auvinen, A
Stenman, UH
Rannikko, S
Tammela, T
Aro, J
Juusela, H
Hakama, M
机构
[1] Finnish Canc Registry, FIN-00170 Helsinki, Finland
[2] Radiat & Nucl Author, Helsinki, Finland
[3] Univ Helsinki, Cent Hosp, Dept Clin Chem, Helsinki, Finland
[4] Univ Helsinki, Cent Hosp, Dept Urol, Helsinki, Finland
[5] Tampere Univ Hosp, Dept Urol, Tampere, Finland
[6] Helsinki City Hosp, Dept Surg, Helsinki, Finland
[7] Jorvi Hosp, Dept Surg, SF-02740 Espoo, Finland
[8] Tampere Univ, Tampere Sch Publ Hlth, FIN-33101 Tampere, Finland
关键词
screening; prostate neoplasms; randomized controlled trials; prostate-specific antigen;
D O I
10.1038/sj.bjc.6690194
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Approximately 20 000 men 55-67 years of age from two areas in Finland were identified from the Population Registry and randomized either to the screening arm (1/3) or the control arm (2/3) of a prostate cancer screening trial. In the first round, the participation rate in the screening arm was 69%. Of the 5053 screened participants, 428 (8.5%) had a serum prostate-specific antigen (PSA) concentration or 4.0 ng/ml or higher, and diagnostic examinations were performed on 399 of them. A total of 106 cancers were detected among them corresponding to a positive predictive value of 27%, which is comparable with mammography screening for breast cancer. The prostate cancer detection rate based on a serum PSA concentration of 4.0 ng ml(-1) or higher was 2.1%. Approximately nine out of ten screen-detected prostate cancers were localized (85% clinical stage T1-T2) and well or moderately differentiated (42% World Health Organization (WHO) grade I and 50% grade II), which suggests a higher proportion of curable cancers compared with cases detected by other means.
引用
收藏
页码:1210 / 1214
页数:5
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