Transcript profile and localization of Wnt signaling-related molecules in human endometrium

被引：22

作者：

Cheng, Ching-wen ^{[1
,2
]}

Smith, Stephen K. ^{[2
]}

Charnock-Jones, D. Stephen ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Pathol, Reprod Mol Res Grp, Cambridge CB2 1QP, England

[2] Univ Cambridge, Dept Obstet & Gynaecol, Cambridge CB2 1QP, England

来源：

FERTILITY AND STERILITY | 2008年 / 90卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.fertnstert.2007.05.077

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The mRNAs encoding several Wnt ligands, Frizzled receptors, and Wnt antagonists were detected in human endometrium, including SFRP1; the levels of SFRP1 mRNA were higher in the proliferative phase of the menstrual cycle and increased in endometriotic tissue compared with control eutopic endometrium, and they were detected in both glandular and stromal cells but were more abundant in the stroma. Our results suggest that Wnt signaling could function in normal endometrial physiology and the the Wnt signalling inhibitor SFRP1 might play a role in endometrial growth and endometriosis development.

引用

页码：201 / 204

页数：4

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