Xenobiotic metabolism genes and the risk of recurrent spontaneous abortion

被引：16

作者：

Hirvonen, A ^{[1
]}

Taylor, JA ^{[1
]}

Wilcox, A ^{[1
]}

Berkowitz, G ^{[1
]}

Schachter, B ^{[1
]}

Chaparro, C ^{[1
]}

Bell, DA ^{[1
]}

机构：

[1] NIEHS,EPIDEMIOL BRANCH,RES TRIANGLE PK,NC 27709

来源：

EPIDEMIOLOGY | 1996年 / 7卷 / 02期

关键词：

glutathione S-transferase M1; N-acetyltransferase; 2; spontaneous abortion; genetic polymorphism; polymerase chain reaction technique; gender;

D O I：

10.1097/00001648-199603000-00018

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We examined the relation between spontaneous abortion and polymorphisms in two genes, glutathione S-transferase (GSTM1) and N-acetyltransferase (NAT2), which are involved in the metabolism of xenobiotics. In a case-control study of 29 women, we found that, among women with the GSTM1 null genotype, the odds ratio (OR) was 3.1 [95% confidence interval (CI) = 1.3-7.0]. There was less evidence of a relation with NAT2 [Mantel-Haenszel adjusted OR (OR(MH)) = 1.4; 95% CI = 0.45-4.3]. We sought to replicate the CSTZ1 finding in an independent case control study from New York involving 89 cases. We found an inverse association (OR = 0.8; 95% CI = 0.4-2.4). Taken together, these data provide little evidence of an association between GSTM1 or NAT2 genotype and risk of spontaneous abortion.

引用

页码：206 / 208

页数：3

共 15 条

[1] GENETIC RISK AND CARCINOGEN EXPOSURE - A COMMON INHERITED DEFECT OF THE CARCINOGEN-METABOLISM GENE GLUTATHIONE-S-TRANSFERASE M1 (GSTM1) THAT INCREASES SUSCEPTIBILITY TO BLADDER-CANCER [J].