Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues

被引：28

作者：

Jain, R

Singh, J

Perlman, JH

Gershengorn, MC

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, Punjab, India

[2] Cornell Univ, Weill Med Coll, Dept Med, Div Mol Med, New York, NY 10021 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0968-0896(01)00265-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：189 / 194

页数：6

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