Imidazoline receptor proteins in brains of patients with Alzheimer's disease

被引：55

作者：

García-Sevilla, JA ^{[1
]}

Escribá, PV

Walzer, C

Bouras, C

Guimón, J

机构：

[1] Univ Geneva, HUG, Fac Med, Dept Psychiat, CH-1225 Chene Bourg, Switzerland

[2] Univ Balearic Isl, CSIC, Dept Biol,Associate Unit, Inst Neurobiol Ramon & Cajal,Lab Neuropharmacol, E-07071 Palma de Mallorca, Balears, Spain

来源：

NEUROSCIENCE LETTERS | 1998年 / 247卷 / 2-3期

关键词：

imidazoline receptor proteins; Western immunoblotting; postmortem human brain; Alzheimer's disease;

D O I：

10.1016/S0304-3940(98)00265-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Imidazoline receptors (29/30- and 45-kDa proteins) were quantitated in postmortem brains of patients with Alzheimer's disease (AD) by using immunoblotting techniques and a specific antiserum. Increased levels of the 29/30-kDa protein (30%), 45-kDa protein (36%) and glial fibrillary acidic protein (88%) were found in the frontal cortex of AD patients. These findings are in line with the reported higher density of imidazoline receptors labelled by [H-3]idazoxan in AD brains, suggesting that these imidazoline receptor proteins are related to the 12-imidazoline receptor located in mitochondria of glial (astrocyte) cells. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：95 / 98

页数：4

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