Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria) -: Fermentation, isolation, physico-chemical properties, structure and biological activity

被引：57

作者：

Kunze, B

Reichenbach, H

Müller, R

Höfle, G

机构：

[1] GBF, German Canc Ctr Biotechnol, Dept Nat Prod, D-38124 Braunschweig, Germany

[2] Univ Saarland, Inst Pharmazeut Biotechnol, D-66123 Saarbrucken, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 04期

关键词：

Myxobacteria; bioactive polyketides; 5-alkenyl-3 3(2H)-furanones; aurafurons;

D O I：

10.1038/ja.2005.28

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New antibiotic polyketides, named aurafuron A (1) and B (2) were isolated from culture extracts of myxobacteria of the species Stigmatella aurantiaca and Archangium gephyra, strain Ar 10844. By multi-step chromatography 1 and 2 were separated from a variety of other non-related co-metabolites, and their structures elucidated by spectroscopic methods as new 5-alkenyl-3 3(2H)-furanones. Aurafurons inhibited the growth of some filamentous fungi and additionally, aurafuron B was weakly active against few Gram-positive bacteria. Both compounds also showed cytotoxic activity against the mouse fibroblast cell line L929.

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页码：244 / 251

页数：8

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