Ipsapirone, a 5-HT1A agonist, suppresses REM sleep equally in unmedicated depressed patients and normal controls

被引:28
作者
Gillin, JC [1 ]
Sohn, JW [1 ]
Stahl, SM [1 ]
Lardon, M [1 ]
Kelose, J [1 ]
Rapaport, M [1 ]
Ruiz, C [1 ]
Golshan, S [1 ]
机构
[1] VET ADM MED CTR,SAN DIEGO,CA 92161
关键词
serotonin; mood disorder; REM latency;
D O I
10.1016/0893-133X(95)00159-B
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To determine whether ipsapirone, a 5-HT1A agonist, differentially suppresses REM sleep in depressed patients compared with normal controls, we administered placebo, ipsapirone 10 mg, or ipsapirone 20 mg in a double-blind, random order before bedtime in 18 unmedicated patients with depression and 16 age-matched, gender-matched normal controls. Compared to placebo, ipsapiuone affected REM sleep measures equally in depressed patients and controls as follows: (1) increased XEM latency; (2) reduced total REM percent, XEM time, and XEM density; and (3) delayed the onset of REM sleep. In addition, ipsapirone had similar effects in patients and controls in other sleep measures: (I) reduced total sleep time; (2) delayed sleep onset time; and (3) increased sleep latency stage 1%, stage 2%, the amount of stage 3 & 4 sleep in the first non-REM period, and wake time after sleep onset. The study does not support the hypothesis that downregulated 5-HT1A receptors mediate the pathophysiology or sleep disturbances of depression, although further studies are needed as these patients did not differ from controls in baseline sleep measures.
引用
收藏
页码:109 / 115
页数:7
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