Anti-endomysial antibody negative celiac disease - Does additional serological testing help?

被引：30

作者：

Dahele, A

Kingstone, K

Bode, J

Anderson, D

Ghosh, S ^{[1
]}

机构：

[1] Western Gen Hosp, Gastrointestinal Unit, Dept Med Microbiol, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Dept Med Sci, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

DIGESTIVE DISEASES AND SCIENCES | 2001年 / 46卷 / 01期

关键词：

anti-gliadin antibodies; anti-endomysium antibodies; anti-tissue transglutaminase antibodies; celiac disease;

D O I：

10.1023/A:1005589202529

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Anti-endomysium antibodies (AEM) fail to identify all untreated celiac disease (CD) patients. This study aims to determine if additional serology, in particular, IgA anti-tissue transglutaminase (tTG) antibodies, increases detection. Fifty-three biopsy-proven untreated CD patients (39 women, 14 men; median age 51 years) and 65 control patients with normal duodenal histology (46 women, 19 men; age range 17-90 years, median 45 years) were prospectively studied. Serum total IgA, IgA anti-tTG, IgA AEM, IgA anti-gliadin (AGA) and IgG AGA antibodies were measured. Thirteen (25%) CD patients were AEM negative. None were IgA deficient. Three AEM-negative CD patients had a raised IgA anti-tTG and IgA AGA. IgG AGA was raised in 10 AEM-negative CD patients, but also in 14/65 (22%) of controls. In conclusion, AEM-negative CD is common and detection is only modestly enhanced by testing for IgA anti-tTG antibodies. Duodenal biopsy is still recommended for the accurate diagnosis of CD.

引用

页码：214 / 221

页数：8

共 37 条

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