Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

被引：153

作者：

Durante, Michael A. ^{[1
,2
,3
,4
]}

Kurtenbach, Stefan ^{[2
,3
]}

Sargi, Zoukaa B. ^{[4
,5
]}

Harbour, J. William ^{[2
,3
,4
]}

Choi, Rhea ^{[1
,2
,6
]}

Kurtenbach, Sarah ^{[2
,5
]}

Goss, Garrett M. ^{[2
,5
]}

Matsunami, Hiroaki ^{[7
,8
]}

Goldstein, Bradley J. ^{[2
,5
,6
,9
]}

机构：

[1] Univ Miami, Miller Sch Med, Med Scientist Training Program, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Interdisciplinary Stem Cell Inst, Miami, FL 33136 USA

[3] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA

[4] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

[5] Univ Miami, Miller Sch Med, Dept Otolaryngol, Miami, FL 33136 USA

[6] Univ Miami, Miller Sch Med, Grad Program Neurosci, Miami, FL 33136 USA

[7] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Duke Inst Brain Sci, Durham, NC USA

[8] Duke Univ, Med Ctr, Dept Neurobiol, Duke Inst Brain Sci, Durham, NC 27710 USA

[9] Duke Univ, Med Ctr, Dept Head & Neck Surg & Commun Sci, Durham, NC 27710 USA

来源：

NATURE NEUROSCIENCE | 2020年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SENSORY NEURONS; MAINTENANCE; EPITHELIUM; PATHWAY;

D O I：

10.1038/s41593-020-0587-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans. Durante et al. report the presence of active neurogenic niches in adult humans using single-cell RNA sequencing of the human olfactory neuroepithelium. Data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.

引用

页码：323 / +

页数：17

共 30 条

[1] Dimensionality reduction for visualizing single-cell data using UMAP [J].