Synthesis of the AB spiroketal subunit of spongistatin 1 (altohyrtin A): The pyrone approach

被引：36

作者：

Crimmins, MT ^{[1
]}

Washburn, DG ^{[1
]}

机构：

[1] Univ N Carolina, Venable & Kenan Labs Chem, Chapel Hill, NC 27599 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(98)01629-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the AB spiroketal fragment of spongistatin 1 (altohyrtin A) has been accomplished utilizing the addition of a metalated pyrone to an aldehyde followed by acid catalyzed spirocyclization. A stereoselective copper (I) promoted conjugate addition of vinylmagnesium bromide was used to establish the C11 stereogenic center. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7487 / 7490

页数：4

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