Assembly, disassembly and recycling The dynamics of exon junction complexes

被引：68

作者：

Bono, Fulvia ^{[1
]}

Gehring, Niels H. ^{[2
]}

机构：

[1] Max Planck Inst Dev Biol, Tubingen, Germany

[2] Univ Cologne, Inst Genet, D-5000 Cologne, Germany

来源：

RNA BIOLOGY | 2011年 / 8卷 / 01期

关键词：

exon junction complex; PYM; UPF3b; NMD; RNA localization; MAGO; Y14; NONSENSE-MEDIATED DECAY; OSKAR MESSENGER-RNA; CRYSTAL-STRUCTURE; MAMMALIAN-CELLS; MAGO NASHI; PROTEIN-COMPOSITION; MOLECULAR INSIGHTS; NUCLEAR IMPORT; CORE COMPLEX; DROSOPHILA;

D O I：

10.4161/rna.8.1.13618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Efficient gene expression requires that, during their lifetime, mRNAs associate with different sets of RNA binding proteins to form messenger ribonucleoprotein particles (mRNPs). The protein components of mRNPs are essential for the correct post-transcriptional function and regulation of mRNAs. mRNPs are constitutively remodeled during the maturation of the mRNA in the nucleus and downstream steps in the cytoplasm, and can also change depending on the cellular environment. Here we review the current understanding of the biochemical and structural aspects of a central mRNP component and regulator, the exon junction complex (EJC).

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页码：24 / 29

页数：6

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