A computer program for aligning a cDNA sequence with a genomic DNA sequence

被引：558

作者：

Florea, L

Hartzell, G

Zhang, Z

Rubin, GM

Miller, W ^{[1
]}

机构：

[1] Penn State Univ, Dept Comp Engn & Sci, University Pk, PA 16802 USA

[2] Drosophila Genome Ctr, Berkeley, CA 94720 USA

来源：

GENOME RESEARCH | 1998年 / 8卷 / 09期

关键词：

D O I：

10.1101/gr.8.9.967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.

引用

页码：967 / 974

页数：8

共 27 条

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