Antipyretic efficacy and safety of ibuprofen and acetaminophen in children

被引：50

作者：

Goldman, RD ^{[1
]}

Ko, K ^{[1
]}

Linett, LJ ^{[1
]}

Scolnik, D ^{[1
]}

机构：

[1] Hosp Sick Children, Div Pediat Emergency Med, Pediat Res Emergency Therapeut Program, Toronto, ON M5G 1X8, Canada

来源：

ANNALS OF PHARMACOTHERAPY | 2004年 / 38卷 / 01期

关键词：

acetaminophen; children; ibuprofen;

D O I：

10.1345/aph.1C391

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children. Data Sources: Searches of MEDLINE (1966-November 2003) and EMBASE (1988-November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed. Data Synthesis: Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other. Conclusions: The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.

引用

页码：146 / 150

页数：5

共 24 条

[1]

AMDEKAR YK, 1985, BRIT J CLIN PRACT, V39, P140

[2]

[Anonymous], PEDIATRICS

[3] Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever [J].