Cellular and molecular characteristics of basal cells in airway epithelium

被引:118
作者
Evans, MJ [1 ]
Van Winkle, LS
Fanucchi, MV
Plopper, CG
机构
[1] Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA
[2] Univ Calif Davis, Sch Vet Med, Ctr Comparat Resp Biol & Med, Davis, CA 95616 USA
关键词
airway epithelium; lateral intercellular space; inflammation; progenitor cell; epithelial-mesenchymal; epithelial attachment;
D O I
10.1080/019021401300317125
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Basal cells exist as a separate layer of cells covering most of the airway basal lamina. In this central position, they can interact with columnar epithelium, neurons, basement membrane , and the underlying mesenchymal cells. In addition, they interact with inflammatory cells, lymphocytes and dendritic cells. These interactions take place in the lateral intercellular space between basal cells. In this central position basal cells become a very important part of the epithelial-mesenchymal trophic unit of layer airways. In this review it is shown that basal cells may function as progenitor cells of airway epithelium and have a role in the attachment of columnar epithelium with the basement membrane. They also have the potential to function in regulation of neurogenic inflammation, the inflammatory response, transepithelial water movement, oxident defense of the tissue and formation of the lateral intercellular space. Other characteristics of basal cells were not clearly associated with a particular function. The functions for basal cells listed attempt to explain the presence of recently identified molecules in basal cells of airway epithelium. It should be pointed out that specific studies have not been carried out which test the relationship between the molecular function we describe in this review and the basal cell in airway epithelium.
引用
收藏
页码:401 / 415
页数:15
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