Regulation of a neuronal form of focal adhesion kinase by anandamide

被引：144

作者：

Derkinderen, P ^{[1
]}

Toutant, M ^{[1
]}

Burgaya, F ^{[1
]}

LeBert, M ^{[1
]}

Siciliano, JC ^{[1
]}

deFranciscis, V ^{[1
]}

Gelman, M ^{[1
]}

Girault, JA ^{[1
]}

机构：

[1] COLL FRANCE,INSERM,CHAIRE NEUROPHARMACOL,U114,F-75231 PARIS 05,FRANCE

来源：

SCIENCE | 1996年 / 273卷 / 5282期

关键词：

D O I：

10.1126/science.273.5282.1719

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Anandamide is an endogenous ligand for central cannabinoid receptors and is released after neuronal depolarization. Anandamide increased protein tyrosine phosphorylation in rat hippocampal slices and neurons in culture. The action of anandamide resulted from the inhibition of adenylyl cyclase and cyclic adenosine 3',5'-monophosphate-dependent protein kinase. One of the proteins phosphorylated in response to anandamide was an isoform of pp125-focal adhesion kinase (FAK+) expressed preferentially in neurons. Focal adhesion kinase is a tyrosine kinase involved in the interactions between the integrins and actin-based cytoskeleton. Thus, anandamide may exert neurotrophic effects and play a role in synaptic plasticity.

引用

页码：1719 / 1722

页数：4

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