Sympathetic nervous control of the cerebral circulation in sleep

Cerebral vessels are extensively innervated by sympathetic nerves arising from superior cervical ganglia, and these nerves might play a protective role during the large arterial pressure surges of active sleep (AS). We studied lambs (n = 10) undergoing spontaneous sleep-wake cycles before and after bilateral removal of the superior cervical ganglia (SCGx, n = 5) or sham ganglionectomy (n = 5). Lambs were instrumented to record cerebral blood flow (CBF, flow probe on the superior sagittal sinus), carotid arterial pressure (P-ca), intra-cranial pressure (P-ic), cerebral perfusion pressure (P-cp = P-ca-P-ic) and cerebral vascular resistance (CVR). Prior to SCGx, CBF (mL min(-1)) was significantly higher in AS than in Quiet Sleep (QS) and Quiet Wakefulness (QW) (17 +/- 2, 13 +/- 3, and 14 +/- 3 respectively, mean SD, P < 0.05). Following SCGx, baseline CBF increased by 34, 31, and 29% respectively (P < 0.05). CVR also decreased in all states by similar to 25% (P < 0.05). During phasic AS, surges of P-ca were associated with transient increases in P-cp, P-ic and CBF. Following SCGx, peak CBF and P-ic during surges became higher and more prolonged (P < 0.05). Our study is the first to reveal that tonic sympathetic nerve activity (SNA) constricts the cerebral circulation and restrains baseline CBF in sleep. SNA is further incremented during arterial pressure surges of AS, limiting rises in CBF and P-ic, possibly by opposing vascular distension as well as by constricting resistance vessels. Thus, SNA may protect cerebral microvessels from excessive distension during AS, when large arterial blood pressure surges are common.