Process research and structural studies on nabumetone

被引:27
作者
Prabhakar, C
Reddy, GB
Reddy, CM
Nageshwar, D
Devi, AS
Babu, JM
Vyas, K
Sarma, MR
Reddy, GO
机构
[1] Dr Reddys Res Fdn, Proc Res & Dev Div, Hyderabad 500050, Andhra Pradesh, India
[2] Dr Reddys Res Fdn, Struct Chem Div, Hyderabad 500050, Andhra Pradesh, India
关键词
D O I
10.1021/op980060d
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A short, simple and economical process for large-scale preparation of nabumetone has been developed. The single-crystal structures of nabumetone and one of its key intermediates have been determined by X-ray diffraction studies. Two impurities have been isolated and characterised.
引用
收藏
页码:121 / 125
页数:5
相关论文
共 23 条
[1]   TABLES OF BOND LENGTHS DETERMINED BY X-RAY AND NEUTRON-DIFFRACTION .1. BOND LENGTHS IN ORGANIC-COMPOUNDS [J].
ALLEN, FH ;
KENNARD, O ;
WATSON, DG ;
BRAMMER, L ;
ORPEN, AG ;
TAYLOR, R .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1987, (12) :S1-S19
[2]  
Arsenijevic L., 1973, ORG SYNTH, V53, P5
[3]  
ASLAM M, 1989, SYNTHESIS-STUTTGART, P869
[4]  
ASLAM M, 1989, Patent No. 376516
[5]  
CHEN Z, 1989, CHIN J PHARM, V20, P146
[6]  
FRITCH JR, 1996, Patent No. 40608
[7]  
GASTER LM, 1978, Patent No. 3643
[8]  
GOUDIE AC, 1978, J MED CHEM, V21, P1260, DOI 10.1021/jm00210a016
[9]  
Lake A. W., 1977, US Patent, Patent No. [4061779, 4,061,779]
[10]  
LAKE AW, 1975, Patent No. 2442305