Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats

被引：30

作者：

Riekkinen, M ^{[1
]}

Riekkinen, P ^{[1
]}

机构：

[1] UNIV KUOPIO,DEPT NEUROL & NEUROSCI,FIN-70211 KUOPIO,FINLAND

来源：

NEUROREPORT | 1997年 / 8卷 / 03期

关键词：

Alzheimer disease; combined therapy; D-cycloserine; nicotine; water maze;

D O I：

10.1097/00001756-199702100-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats. Nicotine (0.3 mg kg(-1), s.c.) or DCS (10 mg kg(-1), i.p.) enhanced acquisition of the WM task. A combination of subthreshold doses of nicotine (0.1 mg kg(-1)) and DCS (3 mg kg(-1)) improved WM acquisition. A subthreshold dose of a competitive NMDA antagonist, CPP (1 mg kg(-1)), blocked the effect of nicotine (0.3 mg kg(-1)) on WM acquisition. A nicotine antagonist, mecamylamine (10 mg kg(-1)), impaired WM acquisition and had no effect on retention, but did not block the effect of DCS 10 mg kg(-1). The results suggest that nicotine and DCS synergistically enhance spatial navigation in aged rats.

引用

页码：699 / 703

页数：5

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