Regulating the onset of mitosis

被引：167

作者：

Ohi, R

Gould, KL

机构：

[1] Vanderbilt Univ, Sch Med, Howard Hughes Med Inst, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Cell Biol, Nashville, TN 37232 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)80036-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In eukaryotes, G(2)/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G(2)/M transition. Altering the spatial organization of G(2)/M regulators also contributes to prevention of mitosis following DNA damage.

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收藏

页码：267 / 273

页数：7

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