RNA folding: models and perspectives

被引：101

作者：

Sosnick, TR ^{[1
]}

Pan, T

机构：

[1] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(03)00066-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intrinsic events during RNA folding include conformational search and metal ion binding. Several experimentally testable models have been proposed to explain how large ribozymes accomplish folding. Future challenges include the validation of these models, and the correlation of experimental results and theoretical simulations.

引用

页码：309 / 316

页数：8

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