Biokinetics of inhaled radioactive methane in rats: A pilot study

被引：12

作者：

Carlisle, SM ^{[1
]}

Burchart, PA ^{[1
]}

McCauley, C ^{[1
]}

Surette, RA ^{[1
]}

机构：

[1] Atom Energy Canada Ltd, Chalk River Labs, Radiat Biol & Hlth Phys Branch, Chalk River, ON K0J 1J0, Canada

来源：

APPLIED RADIATION AND ISOTOPES | 2005年 / 62卷 / 06期

关键词：

internal dosimetry; dosimetric models; radioactive methane; tritium; C-14; biokinetics;

D O I：

10.1016/j.apradiso.2005.01.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Current dosimetric models for radioactive methane assume 1% of inhaled methane is absorbed, all 3 14 activity is converted immediately to [H-3]H2O, and C-14 activity is converted immediately to [C-14]CO2 (50%) and organically bound carbon (50%). Results of a pilot study using rats to test these models suggest the models overestimate uptake but underestimate organic fixation of H-3 and C-14, especially in liver. Also, the biokinetic properties of organically bound 3 H and C-14 in liver were markedly different from other tissues. Preliminary dose estimates based on observed uptake and organic fixation of label suggest current methane models likely overestimate radiation doses from radioactive methane by 3- to 10-fold. Crown Copyright (c) 2005 Published by Elsevier Ltd. All rights reserved.

引用

页码：847 / 860

页数：14

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