Microglia: Multitasking Specialists of the Brain

被引：150

作者：

Casano, Alessandra Maria ^{[1
]}

Peri, Francesca ^{[1
]}

机构：

[1] European Mol Biol Lab, Dev Biol Unit, D-69117 Heidelberg, Germany

来源：

DEVELOPMENTAL CELL | 2015年 / 32卷 / 04期

关键词：

COLONY-STIMULATING FACTOR-1; NECROSIS-FACTOR-ALPHA; SPINAL-CORD-INJURY; IN-VIVO; POSTNATAL-DEVELOPMENT; ALZHEIMERS-DISEASE; CELL-DEATH; HIPPOCAMPAL NEUROGENESIS; PRIMARY PHAGOCYTOSIS; SYNAPTIC PLASTICITY;

D O I：

10.1016/j.devcel.2015.01.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Microglia are macrophages that colonize the brain during development to establish a resident population of professional phagocytes that protect against invading pathogens and contribute to brain development and homeostasis. As such, these cells sit at the interface between immunology and neurobiology. In addition to their key roles in brain physiology, microglia offer a great opportunity to address central questions in biology relating to how migrating cells find their positions in the embryo, adopt a behavior that is appropriate for that position, and interact with their local environment. We aim, in this review, to survey key recent advances in microglial research.

引用

页码：469 / 477

页数：9

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