Proinflammatory and oxidative stress markers in patients with periodontal disease

被引：100

作者：

Borges, Ivan, Jr. ^{[1
]}

Machado Moreira, Emilia Addison ^{[1
]}

Wilhem Filho, Danilo ^{[2
]}

de Oliveira, Tiago Bittencourt ^{[2
]}

da Silva, Marcelo Barreto Spirelle ^{[3
]}

Froede, Ania Silvia ^{[3
]}

机构：

[1] Univ Fed Santa Catarina, Dept Nutr, BR-88040970 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Ecol & Zool, BR-88040970 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Dept Clin Anal, BR-88040970 Florianopolis, SC, Brazil

来源：

MEDIATORS OF INFLAMMATION | 2007年 / 2007卷

关键词：

D O I：

10.1155/2007/45794

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis. Subject and methods. Eighteen subjects were divided in two groups: experimental ( age 52.9 +/- 5.0) and control ( age 51.1 +/- 9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione ( GSSG), thiobarbituric acid reactive substances (TBARS), andmyeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student t test andP <.05. Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group ( P <.05). Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.

引用

页数：5

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