Synthetic studies on pyrrolophenanthridone skeleton from 1-benzoyl-7-iododihydroindole derivatives using palladium-assisted biaryl coupling reactions

被引：12

作者：

Harayama, T ^{[1
]}

Toko, H ^{[1
]}

Hori, A ^{[1
]}

Miyagoe, T ^{[1
]}

Sato, T ^{[1
]}

Nishioka, H ^{[1
]}

Abe, H ^{[1
]}

Takeuchi, Y ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

HETEROCYCLES | 2003年 / 61卷

关键词：

C-H activation; regioselectivity; anhydrolycorin-7-one; oxoassoanine;

D O I：

10.3987/COM-03-S10

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biaryl coupling reaction of 1-benzoyl-7-iododihydroindole derivatives using Pd reagent was examined. 1-[(1,3-Benzodioxol-5-yl)carbonyl]-7-iodo-2,3-dihydroindole gave 4,5-dihydro-7H-[1,3]dioxolo[4,5-k]pyrrolo[3,2,1-de]phenanthridin-7-one, which was formed by connection to a more hindered carbon, as a major product. 1-(3,4-Dimethoxybenzoyl)-7-iodo-2,3-dihydroindole gave oxoassoanine and 10,11-dimethoxy-4,5-dihydropyrrolo[3,2,1-de]phenanthridin-7-one in an almost equal ratio.

引用

页码：513 / +

页数：9

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