Nought May Endure but Mutability: Spliceosome dynamics and the regulation of splicing

被引：115

作者：

Smith, Duncan J. ^{[2
]}

Query, Charles C. ^{[1
]}

Konarska, Maria M. ^{[2
]}

机构：

[1] Albert Einstein Coll Med, Bronx, NY 10461 USA

[2] Rockefeller Univ, New York, NY 10065 USA

来源：

MOLECULAR CELL | 2008年 / 30卷 / 06期

关键词：

D O I：

10.1016/j.molcel.2008.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

引用

页码：657 / 666

页数：10

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