Dianion equivalents corresponding to the polypropionate domain of epothilone B

被引：12

作者：

Harris, CR

Kuduk, SD

Savin, K

Balog, A

Danishefsky, SJ

机构：

[1] Mem Sloan Kettering Canc Ctr, Bioorgan Chem Lab, New York, NY 10021 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 12期

关键词：

epothilone B; aldol; polypropionate; methyl enol ether;

D O I：

10.1016/S0040-4039(99)00221-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modified synthesis of the polypropionate portion of epothilone, which utilizes a novel, diastereoselective aldol reaction of (S)-2-methyl-4-pentenal (4) and the Z-enolate of the tricarbonyl species (3) is reported. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2263 / 2266

页数：4

共 12 条

[1] AOYAMA T, 1984, CHEM PHARM BULL, V32, P3759
[2] Total synthesis of (-)-epothilone A
Balog, A
Meng, DF
Kamenecka, T
Bertinato, P
Su, DS
Sorensen, EJ
Danishefsky, S
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (23-24): : 2801 - 2803
[3] Balog A, 1998, ANGEW CHEM INT EDIT, V37, P2675, DOI 10.1002/(SICI)1521-3773(19981016)37:19<2675::AID-ANIE2675>3.0.CO
[4] 2-O
[5] CHOU TC, 1998, IN PRESS P NAT ACAD
[6] Total synthesis of (-)-epothilone B
May, SA
Grieco, PA
[J]. CHEMICAL COMMUNICATIONS, 1998, (15) : 1597 - 1598
[7] Total syntheses of epothilones A and B
Meng, DF
Bertinato, P
Balog, A
Su, DS
Kamenecka, T
Sorensen, EJ
Danishefsky, SJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (42) : 10073 - 10092
[8] Nicolaou KC, 1998, ANGEW CHEM INT EDIT, V37, P2015, DOI 10.1002/(SICI)1521-3773(19980817)37:15<2014::AID-ANIE2014>3.0.CO
[9] 2-2
[10] An approach to epothilones based on olefin metathesis
Nicolaou, KC
He, Y
Vourloumis, D
Vallberg, H
Yang, Z
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (20): : 2399 - 2401

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