Identification and functional characterization of brainstem cannabinoid CB2 receptors

被引：1151

作者：

Van Sickle, MD

Duncan, M

Kingsley, PJ

Mouihate, A

Urbani, P

Mackie, K

Stella, N

Makriyannis, A

Piomelli, D

Davison, JS

Marnett, LJ

Di Marzo, V

Pittman, QJ

Patel, KD

Sharkey, KA ^{[1
]}

机构：

[1] Univ Calgary, Inst Infect Immun & Inflammat, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Dept Physiol & Biophys, Calgary, AB T2N 4N1, Canada

[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr,Ctr Mol Toxicol, Vanderbilt Inst Chem Biol,Dept Biochem, Nashville, TN 37232 USA

[4] CNR, Inst Biomol Chem, Endocannabinoid Res Grp, Naples, Italy

[5] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA

[6] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA

[7] Univ Washington, Dept Pharmacol Psychiat & Behav Sci, Seattle, WA 98195 USA

[8] Northeastern Univ, Dept Pharmaceut Sci, Ctr Drug Discovery, Boston, MA 02115 USA

[9] Univ Calif Irvine, Dept Pharmacol, Gillespie Neurosci Facil, Irvine, CA 92697 USA

来源：

SCIENCE | 2005年 / 310卷 / 5746期

关键词：

D O I：

10.1126/science.1115740

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors. CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.

引用

页码：329 / 332

页数：4

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