Antibacterial-induced nephrotoxicity in the newborn

被引：51

作者：

Fanos, V ^{[1
]}

Cataldi, L ^{[1
]}

机构：

[1] Univ Verona, Clin Pediat, Osped Policlin Bgo Roma, Dept Pediat, I-37134 Verona, Italy

来源：

DRUG SAFETY | 1999年 / 20卷 / 03期

关键词：

D O I：

10.2165/00002018-199920030-00005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Antibacterials are the primary cause of drug-induced kidney disease in all age groups and these agents bring about renal damage by 2 main mechanisms, namely, direct and immunologically mediated. For some antibacterials (aminoglycosides and vancomycin) nephrotoxicity is very frequent but generally reversible upon discontinuation of the drug. However, the development of acute renal failure with these agents is possible and its incidence in the newborn seems to be increasing. Antibacterials are very often used in the neonatal period especially in very low birthweight neonates. The role of neonatal age in developing nephrotoxicity has still to be defined.

引用

页码：245 / 267

页数：23

共 205 条

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